Yasuyoshi IWATA1, Kanji KOJIMA2, Makoto ISHIDA3, Yukinobu NAKAMURA3, Toshihiko ISHIDA1, Jiro TAKAHARA1
1First Department of Internal Medicine, Kagawa Medical University, 2Department of Radiology, Kagawa Rosai Hospital, 3Department of Internal Medicine, Kagawa Rosai Hospital
Acceleration index, Diabetic nephropathy, Doppler color flow imaging, Pulsatility index, Resistive index
We used Doppler color flow imaging to study resistive index (RI), pulsatility index (PI), and acceleration index (AI), indexes of peripheral vascular impedance, in 106 cases of diabetic nephropathy. Although RI and PI were strongly correlated, no such correlation was found between RI or PI and AI. RI and PI increased as nephropathy developed, attaining values even higher than those found in the early stage of overt nephropathy before creatinine level rose and 24-hour creatinine clearance fell. This suggests that RI and PI may prove to be useful indexes that can be used before the late phase of overt nephropathy, an irreversible stage in the therapy of diabetic nephropathy.