Ultrasonic B-mode images are affected by changes in scatterer distribution in tissue. It is hard to estimate the relationship between the ultrasonic image and the tissue structure quantitatively because we cannot observe the continuous stages of diseased tissue clinically, particularly the beginning stage. In this review, a simulation method of scattering echo that takes into account tissue acoustic structure is presented. The modeling method of scatterer distribution for normal and diffuse diseased livers can determine the expansion of nodules and fibers. Using B-mode images obtained from these scatterer distributions, we can analyze the relationship between the changes in the form of biological tissue and changes in the B-mode images during progressive liver cirrhosis.