SHARMA Pradeep Kumar

Pradeep Kumar SHARMA

Ultrasound International, Muzaffarnagar, India

キーワード :

【Background】
Carotid intima medial thickness and pulse wave velocity are non-invasive makers of arthrosclerosis and have been shown to reliably predict presence and extent of atherosclerotic vascular disease, resulting association in CAD and cerebrovascular events.
【Methods and Results】
64 patients with angiographically proven coronary artery disease and 84 age matched individuals without coronary artery disease but having one or more conventional cardiovascular risk factors and cerebrovascular accidents cases were included in the study. Carotid intima-media thickness（IMT）was measured at three predefined sittes（distal common carotid, carotid bifurcation and proximal internal carotid artery）on each side. Brachial-ankle pulse wave velocity was measured non-invasively. There was no significant difference in gender and presence of cardio-vascular risk factors in the two groups. Mean and maximum intima-medial thickness and brachial-ankle pulse wave velocity were all significantly higher in coronary artery disease patients as compared to patients without coronary artery disease 0.842v.0.657mm, p＜0.0001; 1.076v.0.795mm, p＜0.0001; 1708.63v.1547 cm/s, p＜0.0004 respectively）. There was a significant correlation between brachial-ankle pulse wave velocity and both mean and maximum carotid intima-media thickness in patients with coronary artery disease（r = 0.01 and -0.1 respectively）and cerebrovascular events
【Conclusions】
Presence of significant correlation between carotid intima-media thickness and brachial-ankle pulse wave velocity in patients with coronary artery disease but absence of the same in individuals without major atherosclerotic vascular disease suggests that the correlation between carotid intima-media thickness and brachial -ankle pulse wave velocity becomes stronger with increasing extent of atherosclerosis, thus alarming the incidence of CAD cerebrovascular accidents.