The liver differs from other organs in that it receives a dual blood supply from the hepatic portal vein and hepatic artery. The portal vein, which delivers nutrients and various other substances to hepatocytes, accounts for approximately 70-80% of the total hepatic blood supply. The remaining 20-30% is supplied via the hepatic artery and mainly nourishes the biliary system. Compared with a blood pressure of ＞ 100 mmHg in the hepatic artery, the pressure in the portal vein is as low as 6-8 mmHg, making the latter system susceptible to pathological changes in the liver. Despite being safeguarded by two blood supplies, when infected, for example by the hepatitis C virus, the liver undergoes cycles of necrosis, defluxion, and fibrosis. As the disease state progresses from chronic hepatitis to cirrhosis, the blood flow in the portal vein is reduced, and as if to compensate for this, the arterial blood flow increases. In other words, the hepatic hemodynamic balance between the portal vein and hepatic artery changes from portal vein dominant to hepatic artery dominant. Diagnostic imaging modalities able to quantitate the changes in the hemodynamic balance of the liver are clinically valuable because they enable noninvasive staging of hepatitis C and can be used to predict the timing of interferon treatment or the onset of complications. We have been using arrival time parametric imaging to examine the hemodynamics of the nutrient hepatic blood flow to improve our understanding of the pathological manifestations of liver diseases. Here, we introduce the latest developments in this area.