Purpose: To evaluate risk factors affecting carotid atherosclerosis. Subjects and Methods: Six hundred seventy-eight subjects, who underwent carotid ultrasonographic examination participated in this study of the relation between risk factors of atherosclerosis and influence on intima-media thickness (IMT) of the common carotid artery and plaque score (PS) in the carotid artery. Elevated values were found in results of linear regression analysis by sex when IMT and PS were used as induced variables, and age, history of smoking, diabetes mellitus, hyperlipidemia, hypertension, and obesity served as independent variables.
Results: Factors related to IMT thickening in the common carotid arteries of the men were age (p＜0.0001), diabetes
mellitus (p＝0.0015), and smoking (p＝0.0027); for women, age (p＜0.0001) and hypertension (p＝0.0247). Factors related to PS in men were age (p＜0.0001), smoking (p＜0.0001), diabetes mellitus (p＝0.0038), hyperlipidemia (p＝0.0064), and hypertension (p＝0.0069); in women, age (p＜0.0001) and hyperlipidemia (p＝0.0123). The relation between number of risk factors possessed by men and IMT was not significant in groups 0 (number of risk factors) through 4; however, group 5 showed significant thickening (p＜0.005). PS increased significantly when the number of factors exceeded 3 (p＜0.05). Neither IMT nor PS in varied significantly with number of risk factors possessed. Conclusions: First, age, diabetes mellitus, and history of
smoking were strongly associated with carotid atherosclerosis.. Second, men were more likely to be influenced by these factors than women.