Patel Sneha

Sneha PATEL

東京女子医科大学消化器内科

Institute of Gastroenterology, Tokyo Women’s Medical University

キーワード :

Purpose
Determine the diagnostic ability of Sonazoid-Enhanced Ultrasound （SEUS）, compared to Contrast-Enhanced Computed Tomography （CECT） for hepatic lesions.

Methods
We compared SEUS with CECT in 61 lesions （42 malignant, 19 benign）. Kupffer-cell detection ability of 11 lesions （9 benign, 2 malignant） were assessed by SEUS and SPIO MRI. 31 （12 benign, 19 malignant） were diagnosed by histopathology, 23 malignant lesions by CT and tumor markers and 7 benign lesions by a 2-year follow-up. One of three ultrasound machines were used; Prosound α 10 （Aloka） with ePHD ; a Sequoia 512 （Siemens） with CPS ; or an Aplio XG Toshiba with CHI.

Results
All enhanced on SEUS and CECT. 38 malignant lesions showed washout on CECT and SEUS. 4 malignant lesions showed washout on SEUS but no washout on CECT. These included: a ICC; a schirrous type of HCC （both of which contained fibrous tissue）; a moderately/poorly differentiated HCC associated with a main portal vein tumor thrombosis （PVTT） and a moderately differentiated HCC.12 benign lesions demonstrated no washout on CT and SEUS, while 7 showed ‘washout’ on both.

2 malignant and 2 benign lesions demonstrated no SPIO uptake and SEUS ‘washout’. 5 benign lesions showed SPIO uptake with SEUS ‘no washout’. 1 benign lesion showed SPIO uptake and SEUS ‘washout’. 1 benign lesion demonstrated no SPIO uptake with SEUS ‘no washout’.

Conclusion

CEUS/CECT ‘washout’ correlation rate for benign lesions was 100 ％ and 90.5 ％ for malignant lesions. CECT has limitations in diagnosing malignant lesions however a combination of SEUS and CECT is useful in determining the nature of a malignant lesion.