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英文誌(2004-)

Journal of Medical Ultrasonics

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2000 - Vol.27

Vol.27 No.12

Case Report(症例報告)

(1471 - 1476)

乳腺の非触知微小非浸潤性小葉癌の2例

Sonographic Appearance of Lobular Carcinoma in Situ of the Breast in Two Cases

濵田 充生1, 小西 豊2, 岩崎 信宏3, 杤尾 人司3, 中村 仁美3, 太田 圭子3, 曾我 登志子3, 森本 義人3, 橋本 隆2, 梶原 建熈2

Michio HAMADA1, Yutaka KONISHI2, Nobuhiro IWASAKI3, Hitoshi TOCHIO3, Hitomi NAKAMURA3, Keiko OTA3, Toshiko SOGA3, Yoshito MORIMOTO3, Takashi HASHIMOTO2, Tatehiro KAJIWARA2

1西神戸医療センター臨床検査技術部, 2神戸市立中央市民病院第一外科, 3神戸市立中央市民病院腹部超音波室

1Clinical Laboratory, Nishikobe Medical Center, 5-7-1 Koujidai, Nishi-ku, Kobe 651-2273, Japan, 2First Department of Surgery, Kobe City General Hospital, 4-6 Minatojimanaka-machi, Chuo-ku, Kobe 650, Japan, 3Section of Abdominal Ultrasound, Kobe City General Hospital, 4-6 Minatojimanaka-machi, Chuo-ku, Kobe 650, Japan

キーワード : Breast cancer, Lobular carcinoma in situ, Ultrasonography

Lobular carcinoma in situ (LCIS) of the breast is a rare disease, especially in Japan. That is usually found incidentally in specimens excised during examination of other lesions. It is often multicentric, and it tends to involve the bilateral mammary glands, either synchronously or metachronously. Subsequent invasive cancers can develop more than twenty years after the diagnosis of LCIS. Unlike other types of breast cancer, LCIS consists of small round cells with uniform nuclei and shows scarce stromal reaction; it is therefore more difficult to palpate, prove with aspiration biopsy, and visualize on mammography. Although some workers have described it as a benign lesion and others have regarded it as an intermediate stage in the development of invasive lobular carcinoma, LCIS is generally recognized as a special type of breast cancer. The sonographic appearance of LCIS has rarely been described. Here we present two cases of LCIS detected on sonography performed in follow-up study after surgery for breast cancer or on screening of the side opposite the side with breast cancer. In both cases, the lesion was about 5 mm in diameter and was not palpated preoperatively. We were able to use sonography to detect these small lesions and to diagnose them as malignant. Sonography showed the irregular margin of the lesion in both cases studied here and it detected attenuation in the deeper part of one. We expect that sonography will prove useful in the detection and diagnosis of small LCIS, and it may prevent some cases of overtreatment by radical mastectomy and other methods.