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英文誌(2004-)

Journal of Medical Ultrasonics

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2000 - Vol.27

Vol.27 No.12

Original Article(原著)

(1465 - 1469)

実験乳癌に対する音響化学療法の効果

The Effect of Sonodynamic Therapy on Rat Mammary Cancer

奥山 伸男1, 笹本 修一1, 加藤 信秀1, 高木 啓吾1, 山崎 史朗1, 辻本 志朗2, 弓田 長彦3, 西垣 隆一郎3, 佐々木 一昭4, 梅村 晋一郎4

Nobuo OKUAYMA 1, Syuichi SASAMOTO1, Nobuhide KATOU 1, Keigo TAKAGI1, Shirou YAMAZAKI 1, Shirou TUJIMOTO2, Nagahiko YUMITA3, Ryuichiro NISHIGAKI3, Kazuaki SASAKI4, Shinichiro UMEMURA4

1東邦大学医学部胸部心臓血管外科, 2病院病理, 3東邦大学薬学部, 4日立製作所中央研究所

1Department of Thoracic Cardiovascular Surgery, Toho University School of Medicine, 6-11-1 Omorinishi, Tokyo 143, Japan, 2Department of Pathology, Toho University School of Medicine, 6-11-1 Omorinishi, Tokyo 143, Japan, 3Department of Pharmacology, Toho University School of Pharmaceutical Science, 2-2-1 Miyama, Funabashi-shi, Chiba 274-8570, Japan, 4Center Research Laboratory, Hitachi Co., Ltd., Higashikoigakubo, Kokubunji-shi, Tokyo 185-8601, Japan

キーワード : Breast cancer, Hematoporphyrin derivative, Photodynamic therapy, Sonodynamic therapy, Ultrasound

Sonodynamic therapy is a target therapy that destroys cancer by ultrasound and leaves hematoporphyrin derivative (HpD) intact. We administered this therapy to rats with breast cancer chemically induced by DMBA. Tumor volumes of four treatment groups of rats were compared. The first group was treated only with administration of hematoporphyrin D; the second, with ultrasound irradiation alone; and the third, with a combination of hematoporphyrin D and ultrasound irradiation. The fourth group, the controls, received no treatment. Ultrasound irradiation alone slightly suppressed tumor growth, while hematoporphyrin D alone had no inhibitive effect on tumor growth. Suppression of tumor growth by combined administration of hematoporphyrin D and ultrasound irradiation was remarkable, however. Destruction of tumor tissue was also observed by light microscopy in the cases treated with combined ultrasound irradiation and HpD. We confirmed that the concentration of HpD was higher in the tumor tissue than in the surrounding tissue of the DMBA rats. Sonodynamic therapy appears to offer great promise as a treatment for breast cancers and other cancers that occur near the surface of the body.