Online Journal
IF値: 1.878(2021年)→1.8(2022年)


Journal of Medical Ultrasonics

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1999 - Vol.26

Vol.26 No.11

Original Article(原著)

(1091 - 1098)


Diagnosis of Ischemic Heart Disease by Dipyridamole-exercise Echocardiography

平野 豊, 山本 忠彦, 上原 久和, 小笹 義尚, 山田 覚, 井川 寛, 石川 欽司

Yutaka HIRANO, Tadahiko YAMAMOTO, Hisakazu UEHARA, Yoshihisa OZASA, Satoru YAMADA, Hiroshi IKAWA, Kinji ISHIKAWA


First Department of Internal Medicine, Kinki University School of Medicine, 377-2 Ono-higashi, Osaka-Sayama-shi, Osaka-fu 589-8511, Japan

キーワード : Coronary artery disease, Dipyridamole, Exercise, Stress echocardiography

The diagnostic usefulness of dipyridamole-exercise stress echocardiography in detecting coronary artery diseases was evaluated in 34 consecutive patients, 18 of single-vessel disease, 4 of double-vessel disease and 1 of triple-vessel disease. Two dimensional echocardiographic images were digitized and assigned in a quad-screen format for nonbiased interpretation. Dipyridamole was administered intravenously as follows: 0.56 mg⁄kg over a period of 4 minutes, no medication for the next 4 minutes, and then 0.28 mg⁄kg over 2 minutes. Exercise was then performed at 50 watts for 3 minutes in the 20 to 30 degree left decubitus position on an echo-bed with an ergometer 5 minutes after the dipyridamole infusion. Intravenous aminophylline was administered at a dose of 125 mg over a period of 1 minute when patients complained of chest pain and showed ST depression of more than 0.2 mV at 80 msec from the J point or showed wall motion abnormalities. All patients underwent coronary angiography. Significant coronary artery disease was defined as ≥75% stenosis of the large coronary arteries. Sensitivity of dipyridamole echocardiography versus dipyridamole-exercise echocardiography was 57% versus 87% (p