The diagnostic usefulness of dipyridamole-exercise stress echocardiography in detecting coronary artery diseases was
evaluated in 34 consecutive patients, 18 of single-vessel disease, 4 of double-vessel disease and 1 of triple-vessel disease. Two
dimensional echocardiographic images were digitized and assigned in a quad-screen format for nonbiased interpretation.
Dipyridamole was administered intravenously as follows: 0.56 mg⁄kg over a period of 4 minutes, no medication for the next 4
minutes, and then 0.28 mg⁄kg over 2 minutes. Exercise was then performed at 50 watts for 3 minutes in the 20 to 30 degree
left decubitus position on an echo-bed with an ergometer 5 minutes after the dipyridamole infusion. Intravenous aminophylline
was administered at a dose of 125 mg over a period of 1 minute when patients complained of chest pain and showed ST
depression of more than 0.2 mV at 80 msec from the J point or showed wall motion abnormalities. All patients underwent
coronary angiography. Significant coronary artery disease was defined as ≥75% stenosis of the large coronary arteries.
Sensitivity of dipyridamole echocardiography versus dipyridamole-exercise echocardiography was 57% versus 87% (p