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英文誌(2004-)

Journal of Medical Ultrasonics

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1999 - Vol.26

Vol.26 No.10

Original Article(原著)

(1047 - 1054)

肝細胞癌に対する肝動脈塞栓術後早期の治療効果判定における超音波ドプラ法の有用性について

Clinical Utility of Doppler Ultrasonography on Evaluation of early therapeutic efficacy after transcatheter arterial embolization in patients with hepatocellular carcinoma

日比 敏男1, 熊田 卓2, 竹島 賢治1, 伊藤 益弘1, 野田 孝浩1, 後藤 繁優1, 杉田 文芳1, 佐々 敏1, 市川 秀男1, 中野 哲2

Toshio HIBI1, Takashi KUMADA2, Kenji TAKESHIMA1, Masuhiro ITO1, Takahiro NODA1, Shigemasa GOTO1, Fumiyoshi SUGITA1, Toshi SASSA1, Hideo ICHIKAWA1, Satoshi NAKANO2

1大垣市民病院形態診断室, 2大垣市民病院消化器科

1Department of Morphologic Diagnosis, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki-shi Gifu 503-8502, Japan, 2Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki-shi Gifu 503-8502, Japan

キーワード : Doppler ultrasonography, Dynamic magnetic resonance Imaging , Hepatocellular carcinoma, Transcatheter arterial embolization

This study was undertaken to determine the value of Doppler ultrasonography in the early evaluation of therapeutic efficacy of hepatocellular carcinoma after transcatheter arterial embolization (TAE). Fifty-two nodules in which tumor vascularity had been detected by Doppler ultrasonography before TAE were examined in 41 patients. Doppler signals were evaluated 1 week after TAE, and the results were compared with tumor vascularity as determined by dynamic magnetic resonance imaging (dynamic MRI), which was used as the gold standard. The sonographic signal disappeared in 41 (79%) of the 52 nodules and remained in 11 (21%). All nodules in which intratumor vascularity had been detected showed positive stain on dynamic MRI. Four of 41 nodules in which the sonographic signal disappeard showed positive stain on dynamic MRI. The Sensitivity of Doppler ultrasonography was 73%; specificity, 100%; and accuracy, 92%. Flow signal in deeply (≥5 cm) located small (≤3 cm) nodules tended to be more difficult to detect. We conclude that Doppler ultrasonography warrants use after TAE in the early evaluation as a specific and noninvasive imaging technique.