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英文誌(2004-)

Journal of Medical Ultrasonics

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1999 - Vol.26

Vol.26 No.01

Original Article(原著)

(0011 - 0016)

Sonodynamically Induced Effect of Eosin Y on Isolated Sarcoma 180 Cells

Nagahiko YUMITA1, Shin-ichiro UMEMURA2

1School of Pharmaceutical Sciences, Toho University (2-2-1 Miyama, Funabashi-shi, Chiba-ken 274, Japan), 2Central Research Laboratory, Hitachi, Ltd. (1-280 Higashi-koigakubo, ' Kokubunji-shi, Tokyo 185, Japan)

キーワード : Cell damage, Eosin Y, Sarcoma 180, Sonochemical mechanism, Ultrasound

Sarcoma 180 cells were suspended in air-saturated PBS and exposed to standing-wave ultrasound for up to 60 seconds in the presence and absence of eosin Y (EY). Rate of ultrasound-induced cell damage was enhanced two to three times with 160 μM EY, while no cell damage was observed with EY alone. Histidine significantly inhibited this enhancement, possibly suggesting a sonochemical mechanism.