Nagahiko YUMITA¹, Shin-ichiro UMEMURA²

¹School of Pharmaceutical Sciences, Toho University (2-2-1 Miyama, Funabashi-shi, Chiba-ken 274, Japan), ²Central Research Laboratory, Hitachi, Ltd. (1-280 Higashi-koigakubo, ' Kokubunji-shi, Tokyo 185, Japan)

キーワード : Cell damage, Eosin Y, Sarcoma 180, Sonochemical mechanism, Ultrasound

Sarcoma 180 cells were suspended in air-saturated PBS and exposed to standing-wave ultrasound for up to 60 seconds in the presence and absence of eosin Y (EY). Rate of ultrasound-induced cell damage was enhanced two to three times with 160 μM EY, while no cell damage was observed with EY alone. Histidine significantly inhibited this enhancement, possibly suggesting a sonochemical mechanism.