Online Journal
IF値: 1.878(2021年)→1.8(2022年)


Journal of Medical Ultrasonics

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1997 - Vol.24

Vol.24 No.06

Original Article(原著)

(0851 - 0860)


Evaluation of the Elastic Modulus of the Arterial Wall by Accurate Noninvasive Measurement of Change in Its Thickness

長谷川 英之1, 金井 浩1, 中鉢 憲賢1, 小岩 喜郎2

Hideyuki HASEGAWA1, Hiroshi KANAI1, Noriyoshi CHUBACHI1, Yoshiro KOIWA2

1東北大学大学院工学研究科電気・通信工学専攻, 2東北大学第1内科

1Department of Electrical Engineering, Tohoku University Graduate School of Engineering, 2First Department of Internal Medicine, Tohoku University School of Medicine

キーワード : Atherosclerosis, Change in thickness of arterial wall, Elastic modulus, Small vibration on arterial wall, Acoustic characteristics

Diagnosis of early-stage atherosclerosis requires increase in spatial resolution to several millimeters, corresponding to the size of the macular lesions on the surface of the wall, when making a local evaluation of the acoustic characteristics of the arterial wall. Pulse wave velocity (PWV) ultrasound has been proposed for this purpose. The relation between PWV and Young's modulus in the circumferential direction of the arterial wall makes the noninvasive evaluation of the elastic characteristics of the arterial wall possible. Previously proposed methods do not provide sufficient spatial resolution. Here pulsive ultrasound is used to measure small vibration at the intima and the adventitia of the arterial wall from the surface of the skin accurately. Change in thickness of the arterial wall is obtained by integrating the difference between the two vibration signals at the intima and adventitia. The elastic modulus of the artrial wall is obtained by dividing the difference between systolic and diastolic blood pressure by the resultant change in thickness of the arterial wall, which is normalized by its thickness at diastole. Moreover, the proposed method is applied to evaluation of the elastic modulus of the human carotid artery in vivo.