A pregnant 26-year-old woman (gravida Ⅳ, para Ⅲ) came to the ultrasonography clinic for routine screening at 21 weeks of
gestation. Fetal solitary liver calcification measuring 6×5×4 mm was identified at the left side of the umbilical vein in the left
hepatic lobe. Fetal growth was normal, and there were no other anomalies. The hyperechoic nodule grew gradually until the
28th week, when it measured 8×7×5 mm, but no changes were found thereafter. At 39 weeks and 3 days, the patient was
vaginally delivered of a viable male infant weighing 3004 g. Ultrasonography showed granular hyperechoic lesions in the S2 area
of the left hepatic lobe, and psychomotor developmental delay was found when the infant was 3 months old. Intracranial
calcification was not detected, however. The connection between fetal liver calcification and postnatal psychomotor developmental delay remains obscure.