福田 弘

Hiroshi FUKUDA

山口大学第2内科

Second Department of Internal Medicine Yamaguchi University School of Medicine

キーワード : Blood flow, Coronary artery , Left ventricular diastolic function, Transesophageal echocardiography

To investigate the hemodynamic determinants of diastolic coronary flow, I used transesophageal Doppler echocardiography to analyze left ventricular pressure (LVP) and aortic pressure (AOP, measured with micromanometers), as well as flow velocity in the left anterior descending coronary artery (LAD). Eight of the subjects examined were normal (N); 7 had aortic regurgitation (AR); 14 had LV hypertrophy (LVH); and 3 had dilated cardiomyopathy (DCM). I calculated the time constant (Tc) of LVP decay and the gradient of AOP-LVP difference, the difference between the dicrotic notch of AOP and the lowest LVP (ΔP₁/ΔT₁), as well as between the lowest LVP and the end-diastole (ΔP₂/ΔT₂), and measured mean rates of acceleration (ACR) and deceleration (DCR), and peak velocity (PFV) of LAD flow. ACR was lower in DCM (2.5±0.6 m/sec²) and in LVH (2.9±0.8 m/sec², p2). DCR was higher in AR (1.7±0.9 m/sec²) than it was in N (0.6±0.2 m/sec², p1/ΔT₁. Correlation between DCR and ΔP₂/ΔT₂ was also close (r=0.81, p