Online Journal
電子ジャーナル
IF値: 0.677(2017年)→0.966(2018年)

英文誌(2004-)

Journal of Medical Ultrasonics

一度このページでloginされますと,Springerサイト
にて英文誌のFull textを閲覧することができます.

cover

1993 - Vol.20

Vol.20 No.07

Original Article(原著)

(0436 - 0445)

実験肝腫瘍に対する音響化学療法の試み

Sonodynamic Therapy to Experimental Hepatic Tumor

青柳 徹二1, 飯田 和成1, 松尾 賢二1, 野中 博子2, 佐々木 一昭1, 川畑 健一1, 梅村 晋一郎3, 弓田 長彦1, 西垣 隆一郎1, 梅村 甲子郎4

Tetsuji AOYAGI1, Kazunari IIDA1, Kenji MATSUO1, Hiroko NONAKA2, Kazuaki SASAKI1, Kenichi KAWABATA1, Shin-ichiro UMEMURA3, Nagahiko YUMITA1, Ryuichiro NISHIGAKI1, Koshiro UMEMURA4

1東邦大学医学部第1内科, 2東邦大学医学部病理, 3日立製作所基礎研究所, 4東邦大学薬学部薬物動態学教室

1The First Department of Internal Medicine, Toho University, 2Department of Pathology, Toho University, 3Advanced Recearch Laboratory Hitachi, Ltd., 4School of Pharmacentical Science, Toho University

キーワード : Experimental Hepatic Tumor, MRMT-1, Sonodynamic Therapy, HpD, Phased Array, Transducer

The effect of sonodynamic therapy on MRMT-1 hepatic tumor implanted to rats was investigated. The rat tumor was treated with focused ultrasound at 750 kHz from a prototype phased array transducer 24 hr after an adiministration of hematoporphyrin derivative (HpD). The focal spot with a peak intensity of 280 W/cm2 was scanned laterally in the tumor region resulting in the averaged intensity of 3.5 W/cm2 in the region. The echo texture pattern and the size of the tumor were observed with a 7.5 MHz ultrasound imaging system. The tumor size in the groups treated with ultrasound and HpD showed noticable decrease 24, 48 and 72 hr after the treatment. The size decreased by 11.3% and 16.5%, 48 and 72 hr after the treatment, respectively. The texture pattern changed from hypoechoic to hyperechoic after the treatment. Histopathological observation showed that the sonodynamic treatment with HpD caused necrosis of the tumor tissue and cell-balooning. Slight adverse effects were observed on the skin intervening between the tumor and the transducer and on the normal hepatic tissue surrounding the tumor. These results suggest that the sonodynamic therapy has a potential usefulness for the treatment of hepatic tumor.