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Journal of Medical Ultrasonics

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1992 - Vol.19

Vol.19 No.04

Original Article(原著)

(0268 - 0276)


Clinical and Ultrasonic Follow-up of 55 Small Hypoechoic Nodules (≦1.5 cm) associated with Chronic Liver Disease.

杤尾 人司1, 冨田 周介2, 工藤 正俊2, 平佐 昌弘2, 樫田 博史2, 岡部 純弘2, 三村 純2, 濱田 一美1, 簑輪 和士1, 濱田 充生1, 島田 啓子1, 森本 義人1, 伊吹 康良2, 小森 英司2, 織野 彬雄2, 藤堂 彰男2

Hitoshi TOCHIO1, Syusuke TOMITA2, Masatoshi KUDO2, Masahiro HIRASA2, Hiroshi KASHIDA2, Yoshihiro OKABE2, Jun MIMURA2, Kazumi ONOUE1, Kazushi MINOWA1, Michio HAMADA1, Keiko SHIMADA1, Yoshito MORIMOTO1, Yasuyoshi IBUKI2, Hideshi KOMORI2, Akio ORINO2, Akio TODO2

1神戸市立中央市民病院臨床病理科腹部超音波室, 2神戸市立中央市民病院消化器センター内科

1Section of Abdominal Ultrasound, Kobe City General Hospital, 2Division of Gastroenterology, Kobe City General Hospital

キーワード : Hypoechoic nodules, Adenomatous hyperplasia, Early hepatocellular carcinoma

The outcome of hypoechoic hepatic nodules less than 1.5 cm in diameter was studied with clinical and ultrasonic follow-up carried out over 3 years. The evidence of hepatocellular carcinoma (HCC) was not obtained by angiography, lipiodol CT, or biopsy in these 55 nodules at the time of initial detection. Three years after detection, enlargement of the nodule size was observed in 9 (16%) of the 55 nodules, while the size had not changed in 19 (35%) nodules. Twentyseven (49%) nodules became undetectable with US. Two of the 9 enlarged nod ules were diagnosed as adenomatous hyperplasia and the remaining 7 nodules were diagnosed as HCC at the final diagnosis. HCC was observed to have occurred in a different area from that of the initially detected nodule lesion in patients with 8 of the 19 "unchanged" nodules and 4 of the 27 nodules that disappeared during the three years follow-up. It was concluded that 13% of the hypoechoic nodules less than 1.5 cm and without signs of malignancy develop to HCC, whereas most of those nodules (49%) become undetectable with US, suggesting those are benign nodules.