大久保 直彦, 須永 恭司, 林 佳代, 谷一 芳夫, 右馬 隆之, 津田 信幸, 松浦 隆, 唐川 正洋, 岩坂 壽二, 稲田 満夫

Naohiko OKUBA, Yasushi SUNAGA, Kayo HAYASHI, Yoshio TANIICHI, Takayuki UBA, Nobuyuki TSUDA, Takashi MATSUURA, Mashiro KARAKAWA, Toshiji IWASAKA, Mistuo INADA

関西医科大学第二内科

The Second Dept. of Internal Medicine, Kansai Medical University

キーワード : PTCA, Isometric handgrip exercise, Doppler echocardiography

To investigate the serial changes in left ventricular diastolic filling after percutaneous transluminal coronary angioplasty(PTCA) , isometric handgrip exercise(IHG)•Doppler echocardiography was performed before and after PTCA(3 days, 1 and 3 months, 1 year) in 8 patients with effort angina pectoris(AP). All patients had one vessel disease and had no re-stenosis documented by coronary angiography on 3 months and 1 year after PTCA. Peak rapid filling velocity(R), peak atrial filling velocity(A), and the ratio of peak atrial filling to peak rapid filling velocities(A/R) were measured from the transmitral flow velocity pattern at rest and during IHG. Before PTCA, A/R at rest was significantly higher(1.33±0.12 vs 0.92±0.04, p These results indicate that subclinical impairment of LV diastolic filling lasts for at least 1 year after PTCA, and prolonged impairment of LV diastolic filling after PTCA is likely to occur due to a hibernating myocardium caused by recurrent anginal attack.