A study was conducted on the cause of severe abdominal pain induced by PEIT for HCC.
First, we injected a white dye, which had been dissolved in absolute ethanol, at one site on a fresh bovine
liver. The injection was repeated twice at the same site.
There was minor leakage of the dye during the first injection. But, after the needle was removed
immediately, there was a considerable amount of dye leaked from the site of the puncture. And after the
second injection, a considerable amount of dye leaked from the site of the first puncture.
From these observations, we concluded that the second injection, it takes a long time to lower the
intratumor pressure of the ethanol by a process of coagulation.
Next, we compared the severity of pain when the needle was removed immediately after ethanol
injection and after a lapse of 10 seconds. The pain was significantly less (P<0.01) if the needle was
withdrawn 10 seconds after injection.
It was evident that a certain amount of time must lapse before the needle is withdrawn following ethanol
injection to reduce the reflux of ethanol.