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Journal of Medical Ultrasonics

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1991 - Vol.18

Vol.18 No.07

Original Article(原著)

(0678 - 0684)

Lecithin を用いた超音波造影剤: in vitroでの評価及び実験動物における末梢静脈投与による腹部実質臓器の echo enhancement について

Lecithin Encapsulated Microbubbles as Ultrasonic Contrast Medium: Evaluation in vitro and Intravenous Injection

松沢 徹, 丁子 清, 陳 敏華, 入江 五朗

Tohru MATSUZAWA, Kiyoshi CHOUJI, Binka CHIN, Gorou IRIE


Department of Radiology, Faculty of Medicine, University of Hokkaido

キーワード : Ultrasonography, Contrast medium, Microbubble, Lecithin

As a new ultrasonic contrast medium (USCM), Lecithin-encapsulated microbubbles were produced by sonication. Compared to sonicated solutions of albumin (25%) and glucose (70%), the USCM produced stronger backscatter enhancement for in vitro system and persisted longer. The size of the microbubbles verified by light microscopy (mean 2.8 microns, mode 1.5 microns) was smaller than the microbubbles of other agents previously reported. The effect of intravenous injection of the USCM was evaluated using rabbits. Diffuse echo enhancement of the liver and kidney was demonstrated and persisted for several minutes. This study indicated that lecithin-encapsulated microbubbles may be used intravenously as an USCM.