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英文誌(2004-)

Journal of Medical Ultrasonics

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1985 - Vol.12

Vol.12 No.06

Case Report(症例報告)

(0537 - 0542)

肝および脳に興味ある超音波所見を認めた先天性白血病の1剖検例

Ultrasonogram of the Liver and Brain in a Patient with Congenital Leukemia

軽部 敏昭1, 谷野 定之1, 井嶋 裕子1, 鞭 熙1, 鴨下 重彦1, 伊東 紘一2

Toshiaki KARUBE1, Sadayuki YANO1, Hiroko IJIMA1, Hiromu MUCHI1, Shigehiko KAMOSHITA1, Kouichi ITOH2

1自治医科大学小児科, 2自治医科大学臨床病理

1Department of Pediatrics, Jichi Medical School, 2Department of Clinical Pathology, Jichi Medical School

キーワード : Congenital leukemia, Leukemic cell involvement, Ultrasonic examination, Brain atrophy

 his case report represents some ultrasonographic features of the liver and brain in a patient with congenital leukemia.
 A 22-day-old male infant was admitted to Jichi Medical School Hospital because of systemic multiple bluish-skin nodules. Physical examination revealed marked hepatosplenomegaly. Bone marrow aspiration revealed acute lymphoblastic leukemia. Ultrasonography showed multiple hypoechoic areas surrounding the intrahepatic portal branches. On the other hand, no abnormalities were detected in two-dimensional echoencephalography.
 Clinical remission was achieved 33 days after the start of antineoplastic chemotherapy. Simultaneously the size and ultrasonographic pattern of the liver became normal. A few days after the onset of remission, however, CNS involvement was found. Echoencephalography revealed a slight enlargement of the anterior horn of the lateral ventricles. This tendency was noted in the third ventricle 2 months later, and became pronounced several days before the patient's death (i.e., 6 months after admission).
 This was a rare case in which hepatic involvement and progressive enlargement of brain ventricles in congenital leukemia could be ultrasonographically detected and followed up.