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Journal of Medical Ultrasonics

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2016 - Vol.43

Vol.43 No.Supplement

乳腺 乳腺①


Comb-push Shear wave elastographyの開発と乳腺領域への適用

Development of Comb-push shear wave elastography and initial clinical results on breast lesions

谷川 俊一郎1, 神山 直久1, 三塚 幸夫2, 石田 悠里花2

Shunichiro TANIGAWA1, Naohisa KAMIYAMA1, Yukio MITSUZUKA2, Yurika ISHIDA2

1GEヘルスケアジャパン株式会社超音波製品開発部, 2東邦大学医療センター大森病院臨床生理機能検査部

1Ultrasound Engineering, GE Healthcare Japan, 2Department of Clinical Functional Physiology, Toho University Omori Medical Center, Tokyo.

キーワード :

Ultrasound shear wave elastography is a non-invasive imaging technique which quantifies tissue stiffness by measuring the speed of shear waves. Comb-push shear wave elastography was productized as the fast and robust 2D shear elasticity imaging technique in which multiple laterally distributed acoustic radiation force beams are utilized simultaneously to produce shear waves [1][2][3]. Left figure shows the schlieren image of the ultrasonic waves which three multiple push beams are generated simultaneously. The goal of this study was to evaluate this technology to measure the shear wave velocities of breast lesions and use this to help classify lesions as benign or malignant.
The equipment used was a LOGIQ E9(GE Healthcare)with a 9L-D linear Transducer. The study involved 13 participants examined by first conventional Ultrasound followed by shear wave(in the right figure)and strain elastography for each observed lesion between March 2015 and October 2015. Pathological analysis by biopsy or surgical excision was performed on a total of 13 lesions, revealing 4 fibroadenoma and 9 malignant lesions. For 8 malignant cases, we also measure shear wave velocity of the surrounding subcutaneous fat and grand.
The results showed a significant difference in the mean velocity(m/s)between the 4 fibroadenoma(2.03m/s)and 9 malignant(3.85m/s)lesions. The mean velocity of lesion, grand and surrounding subcutaneous fat were 3.91m/s, 1.95m/s and 1.52m/s respectively(n=8). These differences were not statistically significant, but suggesting that the values did tend to correlate with the histopathological conditions.
Comb-push shear wave elastography was considered a useful and objective tool for evaluating breast lesions.
[1]S Tanigawa et al. Jpn J Med Ultrasonics Vol.42 Sup.(2015)
[2]Mehrmohammadi M et al. IEEE Trans Med Imaging.34(1),97-106.(2015)
[3]Song P et al. IEEE Trans Med Imaging.31(9),1821-1832(2012).