COSGROVE David

David COSGROVE

Hammersmith Hospital, Imperial College / London and King’s College Hospital

キーワード :

David Cosgrove MA, MSc, FRCP, FRCR is an Emeritus Professor and Honorary Consultant in Radiology, Hammersmith Hospital, Imperial College, London and King’s College Hospital, London.
His research centres on evolving applications of diagnostic ultrasound, especially in the field of abdominal and small parts. Examples are first reports of clinically significant ultrasound findings, e.g. the features of biliary tree dilatation, pneumobilia, hæmangiomas, abdominal tumours of various types, thyroid diseases, fatty changes in the liver, the use of Doppler in breast diagnosis and transit time analysis of microbubbles in tumours.
In addition he has an interest in the mechanisms of ultrasound appearances （e.g. artefacts, such as transdiaphragmatic echoes） and on exploring novel means to extract hitherto unavailable information from the ultrasound signals, generally known as “tissue characterisation”. Doppler studies have focused on the clinical evaluation and introduction of new techniques such as colour and power Doppler.Microbubbles as ultrasound contrast agents have become a major field of interest with the establishment of a research team to investigate this unique opportunity both from fundamental and clinical points of view. Fundamental studies include non-linear imaging and quantification of the change in echogenicity with microbubble concentration leading to functional indices and imaging. Clinical studies include phase III trials with a range of microbubble agents （especially in the liver and in tumours） and functional studies （especially in diffuse and focal liver diseases and in tumours）. He has been instrumental in the preparation and publication of a series of guidelines into the clinical uses of contrast agents and is a member of the ACR LI-RADS team which has prepared a section on CEUS in patients at risk of developing HCC to complement the existing lexicons on CT and MR.
Elastography, a recently introduced method of imaging and quantifying tissue stiffness, is in routine clinical use and he has been instrumental in several early and more recent stages in this process. He has headed up in the preparation and publication of European and International guidelines into the clinical uses of elastography and is a member of the QIBA initiative on shear wave speed in diffuse liver diseases.