1Fourth Department of Internal Medicine Tokyo Medical University, 2Medical Imaging, Tronto General Hospital University of Tronto, 3Department of Diagnostic Ultrasound, Medical Imaging Center, Hyogo College of Medicine, 4Division of Gastroenterology and Hpatology, Musashino Red-Cross Hospital
Patterns in ultrasonographic images contrast-enhanced with Levovist® were evaluated for their usefulness in diagnosing liver hemangiomas. Subjects were 97 patients with hemangiomas confirmed by dynamic contrast-enhanced CT, dynamic contrastenhanced MRI, or both. Ultrasonographic images were obtained before intravenous bolus injection of 2.5 g of microbubble contrast agent (300 mg/mL) and in the early vascular, late vascular, and delayed phases. Seventy-two (74%) of 97 hemangiomas showed peripheral enhancement in the vascular phases, and 59 (82%) of 72 hemangiomas showed peripheral nodular enhancement with a progressive centripetal fill-in pattern. These results suggested that contrast-enhanced ultrasonography using Levovist® provides highly accurate information for diagnosing hemangioma.