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英文誌(2004-)

Journal of Medical Ultrasonics

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2001 - Vol.28

Vol.28 No.04

Original Article(原著)

(J681 - J691)

肝の超音波組織性状診断に関する研究 -ラット線維化肝におけるROIの分割化によるRF信号の包絡振幅のヒストグラム解析-

Texture Analysis with the New Method of Segments the Region of Interest into Multiple Layers for RF Amplitude Histogram Analysisin the Fibrous Liver of Rats

藤井 康友1, 谷口 信行1, 高野 隆一2, 王 怡1, 重田 浩一朗1, 尾本 きよか1, 小野 倫子1, 佐藤 泉1, 伊東 紘一1

Yasutomo FUJII1, Nobuyuki TANIGUCHI1, Ryuichi TAKANO2, Yi WANG1, Kouichiro SHIGETA1, Kiyoka OMOTO1, Tomoko ONO1, Izumi SATOH1, Kouichi ITOH1

1自治医科大学臨床検査医学, 2自治医科大学腎臓内科

1Department of Clinical Laboratory Medicine, Jichi Medical School, 2Department of Nephrology, Jichi Medical School

キーワード : histogram, fibrous liver, rat, radio-frequency signal, tissue characterization, ultrasound

To estimate severity of fibrosis without biopsy, the valve of signal-noise-ratio (SNR), skewness, and kurtosis were measured using a 10MHz transducer with the texture analysis in conjunction with an alternative method of evaluating fibrous rat livers. This method segments the region of interest (ROI) into multiple layers (sub-ROIs). In each sub-ROI of a homogenous medium, the histogram of enveloped-amplitude of radio-frequency (RF) backscattered echoes resembles a Rayleigh distribution. In theory, SNR, skewness, and kurtosis for Rayleigh statistics are constant and independent of mean scattering intensity, which is enhanced by such undesirable effects as tissue attenuation, beam diffraction, and incident wave forms. Thus, these values, which are averages of the corresponding sub-ROI values, constitute an unbiased estimator. All fibrous liver specimens were induced using the dimethylnitrosamine method. Fiber content was estimated quantitatively as fibrosis index by computer processing of pathological images obtained by light microscopy. The valve of SNR, skewness and kurtosis, expressed as averages of corresponding values from each sub-ROI, correlated closely with fibrosis index. These results make it possible to predict severity of liver fibrosis from data obtained without resorting to biopsy. This data, obtained from our earlier study on rats, may be used to quantitatively evaluate human hepatitis by measuring these three values. This method may make it possible to estimate degree of severity in chronic liver disease non-invasively.