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英文誌(2004-)

Journal of Medical Ultrasonics

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1996 - Vol.23

Vol.23 No.11

Case Report(症例報告)

(0809 - 0814)

冠血流予備能と左房機能の低下を示した心アミロイドーシスの1例

A Case of Cardiac Amyloidosis Demonstrating a Severe Impairment of Coronary Flow Reserve and Left Atrial Function

添木 武, 福田 信夫, 四宮 寛彦, 武市 直樹, 篠原 尚典, 由井 靖子, 田村 禎通

Takeshi SOEKI, Nobuo FUKUDA, Hirohiko SHINOMIYA, Naoki TAKEICHI, Hisanori SHINOHARA, Yasuko YUI, Yoshiyuki TAMURA

国立善通寺病院循環器科 臨床研究部

Department of Cardiology Institute for Clinical Research Zentsuji National Hospital

キーワード : Cardiac amyloidosis, Coronary flow reserve, Doppler flow wire, Echocardiography, Left atrial dysfunction

Cardiac amyloidosis showing severe impairment of coronary flow reserve and left atrial function in a 75-year-old woman whose transthoracic echocardiogram showed markedly concentric hypertrophy of the left ventricle and the typical “granular sparkling” quality of the myocardium is described here. Transesophageal pulsed Doppler echocardiographic examination showed a restrictive transmitral inflow velocity pattern and marked reduction in flow velocity during atrial systole sampled at the orifice of the left upper pulmonary vein and the left atrial appendage, suggesting left atrial dysfunction. Transesophageal echocardiography also showed thickening of the interatrial septum. In addition, coronary flow reserve (ratio of peak hyperemic to resting coronary blood flow velocity), measured by placing a Doppler guide wire in the left anterior descending artery and administering intracoronary ATP, was severely impaired. Infiltration of the atria and small intramural arteries with amyloid may explain the observed impairment of left atrial function and coronary flow reserve.