We evaluated flow dynamics in the left ventricle related to wall motion abnormality using yideodensitometric analysis of transpulmonary contrast echocardiography. The subjects consisted of 8 normal persons, 22 patients with old myocardial infarction (OMI) and 6 patients with dilated cardiomyopathy (DCM). All 36 subjects underwent two-dimensional echocardiographic examination before, during and after intravenous injection of sonicated albumin as a contrast agent(CA). The washout dynamics of CA at the site of the mitral orifice(a) and mid-left ventricle(b) were assessedusing a dens itometric time-intensity curve. We calculated the heart rate from contrast appearance to half-contrast disappearance at each site, as Ta and Tb, respectively. We obtained contrast enhancement in 28 subjects. The contrast effect showed differences among individuals, and the time-intensity curve showed periodic changes corresponding to respiration. We classified patients with wall motion abnormality into two groups(A, B) according to characteristic findings from densitometry: Group A, Tb-Ta≤3(OMI 9, DCM 1); Group B, Tb-Ta≥4(OMI 8, DCM 2). Subjects for whom we could not obtain contrast enhancement comprised Group C(OMI 5, DCM 3). The 8 normal subjects formed Group N. We compared stroke volume(SV), ejection fraction(EF) and wall motion index(WMI) using Doppler echocardiography among all four groups. Group A had wall motion abnormality, but no dilation of the left ventricle, and SV and EF of Group A were not significantly lower than those of Group N. On the other hand, Group B had more severe wall motion abnormality and a dilated left ventricle, and SV and EF of Group B was significantly lower than in Groups N and A. Group C had the most severe wall motion abnormality and dilated left ventricle. SV and EF of Group C was the lowest among the four groups. The value of Tb-Ta correlated with these parameters of left ventricular function. As the left ventricular function became lower, Tb-Ta became longer. Therefore, we concluded that densitometric analysis of CA is a feasible technique for evaluation of the blood stasis in the left ventricle.