1The First Department of Internal Medicine, School of Medicine, Toho University, 2Department of Ultrasonics Laboratory, Toho University
Myeloproliferative disorder, Splenic blood flow, Myelopoietic function
Splenic hemodynamics in patients with diffuse liver diseases has often been compared with that in hematological diseases. Patients with hematological diseases frequently have splenomegaly caused by various mechanisms. Using an ultrasonic Doppler duplex system for estimation of splenic hemodynamics, we studied the relationship between splenic blood flow volume and Myelopoietic function of the bone marrow in patients with chronic myeloproliferative disorders. This study showed that splenomegaly was prominent, and splenic blood flow volume showed a marked increase. The increase in splenic blood flow volume correlated well with the maximum splenic area. The splenic venous and arterial blood flow volume per unit of splenic area was reduced in patients with chronic myeloproliferative disorders, and showed a positive correlation with % Fe-59 utilization in red cells (% RCU). The remarkable decrease in splenic venous blood flow volume appeared 8-10 weeks after chemotherapy using Busulfan, but splenic arterial blood flow volume remained unchanged after that. These results indicated that the myelopoietic function of the bone marrow influenced splenic blood flow volume somewhat, but splenic blood flow volume was affected by maximum splenic area more than by the myelopoietic function of the bone marrow.