Online Journal
電子ジャーナル
IF値: 0.677(2017年)→0.966(2018年)

英文誌(2004-)

Journal of Medical Ultrasonics

一度このページでloginされますと,Springerサイト
にて英文誌のFull textを閲覧することができます.

cover

1988 - Vol.15

Vol.15 No.01

Original Article(原著)

(0036 - 0044)

VX2移植肝腫瘍に及ぼすMMC-mcとTAEの治療効果の比較−超音波所見と病理組織所見との対比−

Antitumor Effects of Transcatheter Arterial Embolization with Mitomycin C Microcapsules and Spongostan on VX2 Implanted Hepatic Tumors -Comparative Study of Ultrasonographical and Histopathological Findings-

甲田 正二郎

Shojiro KODA

東邦大学医学部第一内科

The First Department of Internal Medicine, Toho University School of Medicine

キーワード : VX<SUB>2</SUB> implanted hepatic tumor, Mitomycin C microcapsule, Transcatheter arterial embolization, Ultrasonography, Histopathological findings

We explored the antitumor effects of intra-arterial injection with Mitomycin C microcapsules (MMC-mc), 225 μm in diameter, in comparison with intra-arterial injection of spongostan, 0.5 mm in diameter, on VX2 hepatic tumors implanted in 55 rabbits, in terms of serum concentration of MMC, growth rate of the tumor, ultrasonographical images and histopathological findings.
Before treatment, VX2 tumors, each about 20 mm in diameter, were found by echography to be hyperechoic in the center, with the rest of the tumor being hypoechoic; histopathologically they showed well-circumscribed nodular lesions with central multifocal necrosis. The tumor growth was as well suppressed in the MMC-mc (1 mg/kg) group as in the TAE group. The serum concentration of MMC proved to be (73.33±10.47)×10-4 μg/ml 48 hours after treatment. Echographically, in the MMC-mc group, strongly hyperechoic spots were observed in the tumor after 15 minutes. However, after 24 hours, there appeared a very strong, almost anechoic, hypoecho in the center, a hyperecho around it, and hypoecho in the periphery. Four days after treatment, the tumors were occupied with an overall very strong hypoecho, demarcated with a marginal ring-like hyperecho. In the TAE group, the tumors became hypoechoic, whereas the surrounding liver tissue became rather hyperechoic. Histopathologically, the tumors underwent degeneration and necrosis both in the MMC-mc group and in the TAE group, but infarction was stronger and more widespread in the latter.