The effects of dopamine on the left ventricular regional wall motion were studied in 12 patients with dilated cardiomyopathy by 2-D echocardiography and were compared with the uptake of 201-Thallium. There were no significant responses of heart rate after dopamine infusion (6 μg/kg/min). However, the administration of dopamine reduced PEP/ET significantly, and increased systolic blood pressure, fractional shortening, ejection fraction, and mVcf significantly. The areas of abnormal wall motions were decreased from 58% to 29% of 231 segments after dopamine infusion. Reduced thallium-uptake areas were found in 33% of normal segments, and 81% of the dopamine nonresponding segments. These results demonstrated the correlation between the response of regional wall motion to dopamine and the thallium-uptake. However, the regional wall motion and the thallium-uptake showed different reactions after dopamine administration in some segments. Thus, by examining these findings, we expected more accurate evaluation of myocardial residual functions and viability.